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EXHIBIT 10.46

SECURITIES ACCOUNT CONTROL AGREEMENT

     This agreement, dated as of October 27, 2008 (this “Agreement”) sets forth the agreement between DEUTSCHE BANK SECURITIES INC. (the “Intermediary”), BioMimetic Therapeutics, Inc., a Delaware corporation (the “Debtor”), and Deutsche Bank AG, Cayman Islands Branch and its affiliates referred to in Section 9 (the “Secured Party”). All references herein to the “UCC” shall mean the Uniform Commercial Code as in effect in the State of New York.

      Section 1. Establishment of Securities Account . The Intermediary hereby confirms that:

          1.1 Account Number and Name . The Intermediary has established account number 5XR 209589 (hereinafter referred to as the “Securities Account”) and the account is maintained in the name of the Debtor.

          1.2 Status as a Securities Account . The Securities Account is a “securities account” as such term is defined in Section 8-501(a)
of the UCC.

      Section 2. Maintenance of Securities Account .

          2.1 Clearance and Settlement . Debtor and Secured Party understand and agree that any clearing and settlement firm used by Intermediary in administering the Securities Account is not authorized to accept, and Debtor and Secured Party agree not to attempt to give, instructions to such firm. The Securities Account shall include any sub-accounts as may be established for its proper administration and maintenance.

          2.2 Securities Account .

               2.2.1 The Securities Account will be used solely to hold financial assets as collateral for the Secured Party provided that, in the sole discretion of Secured Party, Secured Party may approve the trading of financial assets held in the Securities Account.

               2.2.2 The Debtor understands and agrees that each of Intermediary (to secure the obligations provided for in Section 3 below) and Secured Party has a lien on the Securities Account. Secured Party has a first lien on the Securities Account. The Debtor agrees that no additional liens shall be permitted without the prior written consent of the Secured Party.

          2.3 Entitlement Orders Given by the Secured Party . If at any time the Intermediary shall receive an entitlement order (as such term is defined in the UCC) in substantially the form set forth as Exhibit A from the Secured Party directing transfer or redemption of any financial asset credited to the Securities Account or any free credit balances with respect to such Securities Account (hereinafter an “Entitlement Order”), the Intermediary shall comply with such Entitlement Order without further consent by the Debtor or any other person.

 


 

          2.4 Debtor’s Rights to Instruct the Intermediary Prior to Delivery of a Notice of Sole Control .

               2.4.1 Securities Account . The Intermediary will not honor any instructions from the Debtor with respect to (i) orders from the Debtor to redeem or transfer financial assets in the Securities Account or (ii) orders from the Debtor to trade financial assets in the Securities Account. However, Intermediary will honor instructions from the Debtor with respect to the exercise of voting rights until Intermediary has received a written notice from Secured Party that Debtor shall no longer be entitled to exercise such voting rights.

               2.4.2 Entitlement Order . In the event that the Intermediary receives an Entitlement Order from the Secured Party that is inconsistent with any order and/or instructions received from the Debtor, the Intermediary shall honor the Entitlement Order of the Secured Party.

          2.5 Notice of Sole Control . Without limiting the provisions of Section 2.4.1, if at any time the Intermediary shall receive from the Secured Party a Notice of Sole Control in substantially the form set forth in Exhibit B hereto, the Intermediary agrees that after receipt of such notice, it will take all orders and instructions (including but not limited to instructions and/or orders with respect to voting, selection of investments, redemption and transfer) with respect to the Securities Account (or, if applicable, the specific security entitlements so identified in such notice) solely from the Secured Party and thereafter shall not honor any orders or instructions of the Debtor with respect to the Securities Account (or, if applicable, the specific security entitlements so identified in such notice). In the event that a Notice of Sole Control identifies only particular security entitlements, and not all security entitlements, with respect to the Securities Account, the Secured Party may thereafter send one or more additional Notices of Sole Control identifying additional securities entitlements.

          2.6 [Intentionally Omitted.]

          2.7 Intermediary’s Duties With_Respect_to Agreements between the Debtor and the Secured Party . The Intermediary shall have no duty or obligation whatsoever of any kind or character to determine whether or not an event of default exists under any agreement between the Debtor and the Secured Party. The Intermediary shall honor Entitlement Orders and/or a Notice of Sole Control irrespective of any knowledge of the Intermediary whether or not an event of default shall exist or the Secured Party shall have any agreement with the Debtor limiting or conditioning its right to give such Entitlement Orders or Notice of Sole Control.The Intermediary shall have no duty to investigate the circumstances under which the Secured Party is entitled to give any Entitlement Orders or Notice of Sole Control.

          2.8 “Financial Assets” Election . The Intermediary hereby agrees that each item of property, including cash, credited to the Securities Account on or after the date of the Agreement shall be treated as a “financial asset” within the meaning of Section 8-102(a)(9) of the UCC.

          2.9 Statements . The Intermediary will send copies of all monthly statements concerning the Securities Account and/or any


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