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EXHIBIT 10.1

AGREEMENT

This Agreement, entered into on this 28th day of October, 2005, is made

Between

Cell Therapeutics, Inc., a company incorporated under the Laws of the State of Washington, with registered offices at 501 Elliot Avenue West 400, Seattle, Washington 98119, U.S.A., represented by Mr. James A. Bianco, in his capacity as president and CEO (hereinafter, “CTI”)

- on one side -

and

Pharmaceutical Research Associates, Inc., a company incorporated under the Laws of the State of Virginia, with its registered offices at 12120 Sunset Hills Road, Suite 600, Reston, Virginia, 20190, U.S.A., represented by Patrick K. Donnelly, in his capacity as President and CEO (hereinafter, ‘‘PRA”)

- on the other side -

(hereinafter, collectively, the “Parties”)

WHEREAS

a)

 

CTI is an American listed biotech company, which operates in the field of research and development of drugs for the curing of tumours;

 

 

 

b)

 

PRA is an American listed company specialized in the performance of services of planning, organization and management of clinical trials;

 

 

 

c)

 

On or about September 24, 2002, the Parties entered into an agreement for the supply of clinical trials development services in relation to the therapeutic protocol No. AZA-III-02, named “An open label, randomized, phase III comparative trial of BBR2778 + Rituximab versus Rituximab in the treatment of patients with relapsed or refractory indolent Non- Hodgkin’s Lymphoma” (hereinafter, the “Clinical Trial Agreement”);

 

 

 

d)

 

The Parties have been involved in a dispute arising out of the Clinical Trial Agreement;

 

 

 

e)

 

In particular, the Parties were involved in an ICC Arbitration Proceedings under the Rules of the ICC International Court of Arbitration pursuant to the arbitration clause contained in Art. 22 of the Clinical Trial Agreement, with venue in Zurich, Switzerland (hereinafter, the ICC arbitration proceedings, the “Arbitration Proceedings”, and the International Chamber of Commerce of Paris, the “ICC”);

 

 

 

f)

 

The Arbitration Proceedings was concluded with the issue of an award rendered on September 27, 2005 (hereinafter, the “Award”), communicated to both of the Parties with an ICC letter dated October 3, 2005, received by CTI and by PRA on October 5, 2005;

 

 

 

g)

 

In accordance with the provisions of the “Operative Part of the final Award&#822


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