EXHIBIT 10.4 AMENDMENT NO. 1 TO TRANSACTION DOCUMENTS

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EXHIBIT 10.4

AMENDMENT NO. 1 TO TRANSACTION DOCUMENTS

Amendment No. 1 to Transaction Documents ("Amendment No. 1"), dated as of

November 26, 2004, between PROVECTUS PHARMACEUTICALS, INC. ("Provectus") and

GRYFFINDOR CAPITAL PARTNERS I, L.L.C. ("Gryffindor").

RECITALS

A. Provectus, Gryffindor and others are parties to a Convertible Secured

Promissory Note and Warrant Purchase Agreement dated as of November 26,

2002 (the "Original Purchase Agreement"), pursuant to which Provectus sold

to Gryffindor, and Gryffindor purchased from Provectus, a Note and a

Warrant.

B. To secure its obligations under the Note, Provectus executed and delivered

to Gryffindor a Security Agreement, a Trademark Collateral Security

Agreement, a Patent and License Security Agreement, a Copyright Security

Agreement and a Stock Pledge Agreement, each dated as of November 26, 2002

(collectively the "Provectus Security Documents").

C. To further secure Provectus' obligations under the Note, Xantech

Pharmaceuticals, Inc., a wholly owned subsidiary of Provectus ("Xantech"),

executed and delivered to Gryffindor a Guaranty, dated as of November 26,

2002 (the "Guaranty"), guarantying the obligations of Provectus under or in

connection with the Note, any Transaction Document and any other document

or instrument executed in connection therewith.

D. To secure its obligations under its Guaranty, Xantech executed and

delivered to Gryffindor a Security Agreement, a Trademark Collateral

Security Agreement, a Patent and License Security Agreement and a Copyright

Security Agreement, each dated as of November 26, 2002 (the Xantech

Security Documents, and together with the Provectus Security Documents, the

"Security Documents").

E. Provectus and Gryffindor also entered into a Registration Rights Agreement,

and Provectus, Gryffindor and others entered into a Shareholders'

Agreement, each dated as of November 26, 2002, which, together with the

other documents referred to in the Original Purchase Agreement are referred

to herein as the "Transaction Documents".

F. Provectus desires to amend the Note to extend the maturity date thereof and

to add the accrued interest thereon to the principal thereof and Gryffindor

is willing to agree to an extension of the maturity date of the Note and to

add the accrued interest thereon to the principal thereof on the terms and

subject to the conditions hereinafter set forth. Accordingly, the parties

hereto agree as follows:

1. Definitions. Capitalized terms used but not otherwise defined herein shall

have the meaning ascribed thereto in the Original Purchase Agreement.

<PAGE>

2. Amendments. Effective as of the date hereof, but subject to the

satisfaction of the conditions precedent set forth in Section 3 hereof, the

following Transaction Documents are hereby amended as follows:

2.1. Note. The Note is amended and restated as set forth in Exhibit A attached

hereto and made a part hereof.

2.2. Registration Rights Agreement. The Registration Rights Agreement is amended

as follows:

(a) For the avoidance of doubt, the defined term "Transactions" in the

Registration Rights Agreement shall be deemed to include the

transactions pursuant to Amendment No. 1 to Transaction Documents,

dated as of November 26, 2004, between Provectus and Gryffindor, and

the documents executed and delivered in connection therewith.

(b) The definition "Shelf Registration Statement" in the Registration

Rights Agreement shall be amended and restated as follows:

"Shelf Registration Statement" shall mean a Registration Statement

filed pursuant to Rule 415 of Regulation C promulgated under the

Securities Act (or any successor rule).

shall be ame

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