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Exhibit 10.44

Execution Copy

Confidential

SOFTWARE LICENSE AGREEMENT

Software License Agreement (this “Agreement”) dated as of May 1, 2009, (the “Effective Date”) by and between CombinatoRx, Incorporated, 245 1 st Street, Fourth Floor, Cambridge, Massachusetts 02142 (“CombinatoRx”) and Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139 (“Novartis”).

 

1.

GENERAL : CombinatoRx and Novartis agree that the terms and conditions set forth in this Agreement apply to the license of the software and components set forth on Annex 1 (the “Software”) and any documentation related to the Software (the “Documentation”). Documentation shall include all user manuals and supplements which refer to or apply to the Software.

 

2.

COLLABORATION AGREEMENT : This Agreement is entered into concurrently with that certain Research Collaboration and License Agreement (the “Collaboration Agreement”) dated as of the date hereof by and between CombinatoRx and Novartis. The signature(s) of each party hereto shall not be effective until both parties have also signed the Collaboration Agreement, and the signature(s) of each party to the Collaboration Agreement shall not be effective until both parties have also signed this Agreement. Capitalized terms not otherwise defined herein shall have the meaning set forth in the Collaboration Agreement.

 

3.

LICENSE : CombinatoRx hereby grants to Novartis and its Affiliates a nonexclusive, worldwide, royalty free license during the Term to use the Software and Documentation to carry out the Research Collaboration and for other internal research purposes (the “License”). The number of copies of Software permitted to be installed and used by Novartis and its Affiliates shall be unlimited. Novartis and its Affiliates may make copies of the Software and the Documentation as needed for installation, maintenance and backup purposes.

Novartis and its Affiliates shall not decompile the Software, but may test the Software and integrate the Software with any systems and software that are proprietary to Novartis or its Affiliates and/or provided or developed by third parties and owned by or licensed to Novartis or its Affiliates. Novartis and its Affiliates may also make the Software and the Documentation available to third party independent contractors working at their facilities under the direction of Novartis’ or its Affiliates’ employees (for example, outsourced IS/IT support).

The License does not include any ownership rights in or rights to sublicense, market or resell the Software or the Documentation. Novartis acknowledges CombinatoRx’s proprietary rights in the Software and the Documentation and agrees to reproduce all copyright notices and disclaimers on all copies of the Software and Documentation.


4.

CONSIDERATION : The License shall be fully paid up for the Initial Term pursuant to the consideration paid to CombinatoRx under Section 5.1(a) of the Collaboration Agreement. The consideration for each Subsequent Term shall be three million US Dollars ($3,000,000) per Subsequent Term, payable within sixty (60) days after Novartis receives CombinatoRx’s invoice for the same, such invoice to be sent after the first day of such Subsequent Term and substantially in the form of Schedule I to the Collaboration Agreement.

 

5.

OWNERSHIP OF RESULTS : Novartis (or its Affiliates, as applicable) shall solely own any and all results, data, inventions (whether or not patentable), copyright and know-how generated by or through Novartis’ or its Affiliates’ use of the Software and the Documentation outside of the Research Collaboration. Ownership of all results, data, inventions (whether or not patentable), copyright and know-how generated by or through Novartis’ or its Affiliates’ use of the Software and Documentation to carry out the Research Collaboration shall be as set forth in the Collaboration Agreement.

 

6.

DELIVERY OF SOFTWARE AND DOCUMENTATION : CombinatoRx shall make the Software available via download or physical media (as appropriate) to Novartis and its Affiliates promptly after the Effective Date, provided that the installation of the Software shall be governed by Section 7. CombinatoRx shall also provide Novartis and its Affiliates with a reasonable number of copies of the Documentation in electronic or hard copy form (as appropriate). Any keys or codes required to “unlock” or enable the installation and/or operation of the Software will be provided along with the Software.

 

7.

INSTALLATION, TECHNICAL SUPPORT AND MAINTENANCE : CombinatoRx shall provide all reasonable support required by Novartis and its Affiliates to facilitate the initial installation of the Software and technology transfer necessary or useful to implement the Software at Novartis in Cambridge, Massachusetts at no additional cost, pursuant to the software implementation and support plan attached to this Agreement as Annex 2 and incorporated herein. CombinatoRx shall complete the initial installation and technology transfer no later than the end of the sixth (6 th ) week after the Effective Date. CombinatoRx personnel shall not be required to travel outside the Boston metropolitan area (including Cambridge, Massachusetts) to support the installation of the Software outside of Cambridge, Massachusetts. In addition, CombinatoRx shall provide up to two hundred (200) hours of support per year of the Term at no cost. CombinatoRx shall notify Novartis in writing when one hundred eighty (180) hours of support have been used in eac


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