Exhibit 10.10

September 27, 2000

Russell Olson

2084 Royale Court

Eagan, MN 55122

Via Fax: 651-454-1480

Dear Russ:

I am pleased to offer you the position of Vice President, Regulatory and Quality at CryoCor, Inc. (the “Company”) with a starting date of October 16, 2000. We anticipate your efforts, and therefore salary, will initially be based on 75% of full time and will transition to 100% on November 6, 2000. This timing of your efforts can accelerate to 100% at an earlier date than November 6, 2000 should you notify me of your desire to make this change. This position will report to me. This offer and your employment relationship will be subject to the terms and conditions of this letter.

Your initial salary will be $12,916.67 per month (or $155,000 annually), less applicable withholdings, paid in accordance with the Company’s normal payroll practices. This position is an exempt position, which means you are paid for the job and not by the hour. Accordingly, you will not receive overtime pay if you work more than 8 hours in a work day or 40 hours in a workweek.

You will receive, subject to the approval of the Company’s Board of Directors, an option to purchase 75,000 shares of the Company’s common stock in accordance with the CryoCor, Inc. 2000 Stock Option Plan (the “Plan”) and related option documents. The exercise price for such shares will be the fair market value on the actual date of the option grant. Such options shall be subject to a Notice of Grant of Stock Option and Stock Option Agreement, which will be provided