Exhibit 10.1

CONVERTIBLE SUBORDINATED PROMISSORY NOTE MATURITY DATE

FOURTH EXTENSION AGREEMENT

Whereas, Bioject Medical Technologies Inc., an Oregon corporation (the “Company”), borrowed $508,896 from Life Sciences Opportunities Fund II (Institutional), L.P. , a Delaware Limited Partnership (the “Lender”), pursuant to that certain Convertible Subordinated Promissory Note, dated as of December 5, 2007(the “Note”); and

Whereas, the Maturity Date of the Note was extended from May 15 2009 to July 15, 2009, pursuant to an Extension Agreement dated April 6, 2009, between the Company and the Lender; the Maturity Date of the Note was further extended from July 15, 2009 to August 15, 2009, pursuant to the Second Extension Agreement