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Exhibit 10.1

JAGOTEC AG

12 June 2009

Cornerstone Therapeutics Inc.
1255 Crescent Green Drive, Suite 250
Cary, NC 27518
USA

Dear Sirs

Manufacturing and Supply Agreement dated 20 August 2007 between Cornerstone Therapeutics Inc. (“Cornerstone,” formerly known as Critical Therapeutics, Inc.) and Jagotec AG (“Jagotec”) and (for the purposes of Clause 20 only) SkyePharma PLC (“MSA”)

We write in connection with Clause 9.1 and Schedule 1 of the MSA.

The parties have agreed that:-

1.

 

The Price for all Product delivered in the Years 2009 (whether before or after the date of this letter) and 2010 shall be US$[***] per [***] tablets of Product. As a result of the increase, Jagotec shall issue to Cornerstone a further invoice for any additional amounts due fo


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