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EXHIBIT 10.12

(GRAPHIC)

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE 4. REQUISITIONPURC N/A 2. AMENDMENT/MODIFICATION NO: Seven (7) 3. EFFECTIVE DATE See block 16C PAGE OF PAGES 1 I 2 5. PROJECT NO. (If applicable! N/A CODE 6. ISSUED BY Btomedical Advanced Research and Development Authority U.S. Department of Health and Human Services 330 Independence Avenue, SW Room G640 Washington, DC 20201 7. ADMINISTERED BY [If other than item 6) CODE 8. NAME AND ADDRESS OF CONTRACTOR (Wo,, street, county. State and ZIP Code) SioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham, AL 35244 DUNS 61-819-4609 TIN 62-1413174 9A. AMENDMENT OF SOLICITATION NO, 9B. DATED {SEE ITEM 11) CODE FACILITY CODE 10A. MODIFICATION OF CONTRACT/ ORDER HHSO1002OO700032C 10B. DATED (SEE ITEM 13) 01-03-07 11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS ” The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers “’ is extended, “ is not extended. Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on sach copy of the offer submitted; or |c) By
separate letter or telegram which includes a reference to thB solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PR


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