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TitlePartiesLaw FirmDateGov Law 
FIFTH AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  INVITAE CORP
 BROE HOLDINGS, LLC
 Casdin Partners, GP, LLC
 Invitae Corporation
 JE Flynn Capital, LLC
 OrbiMed Advisors LLC
 OrbiMed Capital GP V LLC
 PERCEPTIVE LIFE SCIENCES MASTER FUND, LTD
 REDMILE CAPITAL OFFSHORE FUND II, LTD
 REDMILE SPECIAL OPPORTUNITIES FUND, LTD
 Rock Springs GP LLC
 Thomas, McNerney & Partners II, LLC
 TITAN PERC LTD
 TMP NOMINEE II, LLC
Pillsbury Winthrop1/15California
INVESTOR RIGHTS AGREEMENT between FIRST AMERICAN FINANCIAL HOLDINGS, INC. and GOLDMAN, SACHS & CO., dated as of February 15, 2007 Table of Contents  AVENUE FINANCIAL HOLDINGS, INC.
 FIRST AMERICAN FINANCIAL HOLDINGS, INC
 Goldman, Sachs & Co
 Principal Strategies Group
Sullivan Cromwell1/15New York
HTG MOLECULAR DIAGNOSTICS, INC. AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  HTG MOLECULAR DIAGNOSTICS, INC
 Fletcher Spaght Associates II-B, LLC
 FSA II, LLC
 MERCK CAPITAL VENTURES, LLC
 Solstice Capital LLC
 SR ONE, LIMITED
Palmer Dodge;Edwards Angell12/14Unavailable
INVESTORS' RIGHTS AGREEMENT TABLE OF CONTENTS  SPARK THERAPEUTICS, INC.
 BlackRock Advisors, LLC
 BlackRock Capital Management, Inc
 BLACKROCK GLOBAL FUNDS
 BlackRock Investment Management, LLC
 JE Flynn Capital, LLC
 John Hancock Funds
 John Hancock Variable Insurance
 SIGAL FAMILY INVESTMENTS, LLC
 Sofinnova Management VIll, LLC
 Spark Therapeutics, Inc
 Spark Therapeutics, LLC
 T ROWE PRICE ASSOCIATES, INC
 T Rowe Price Health Sciences Fund, Inc
 T Rowe Price New Horizons Fund, Inc
 TD Mutual Funds
 Valic Company
O'Melveny Myers;Wilmer Cutler12/14Delaware
AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  FLEX PHARMA, INC.
 FLEX PHARMA, INC
 Sills Cummis & Gross PC
Sills Cummis;Lowenstein Sandler;Covington Burling12/14Massachusetts
Wausau Paper Terminates Shareholder Purchase Rights Plan Declares $0.03 Dividend  WAUSAU PAPER CORP.
 Wausau Paper Corp
Unavailable12/14Unavailable
ROCKET FUEL INC. FIFTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  ROCKET FUEL INC.
 ARES CAPITAL CORPORATION
 ATV Associates VIII, LLC
 BERRY PATCH, LLC
 BLUE CHIP IV LIMITED PARTNERSHIP
 Blue Chip Partners LLC
 BLUE CHIP V LLC
 Blue Chip Venture Company, Ltd
 CHIPSTONE FOUNDATION
 Denali Acquisition Sub II, LLC
 Denali Acquisition Sub, Inc
 Echelon Ventures, LLC
 Hudson Ventures II, LLC
 INTEL CAPITAL CORPORATION
 LEWIS WHARF PARTNERS
 Marlin Group, LLC
 MILLENNIUM TRUST CO, LLC
 NG Partners II, LLC
 Ninth MDV Partners, LLC
 ROCKET FUEL INC
 Shareholder Representative Services LLC
 STONE & CO
 Wilson Sonsini Goodrich & Rosati, PC
 WS INVESTMENTS III, LLC
 X Plus Two Solutions, Inc
Wilson Sonsini11/14California
AMENDMENT TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  CHIMERIX INC
 A M Pappas & Associates, LLC
 AMP&A Management III, LLC
 AMP&A Management IV, LLC
 CHIMERIX, INC
 Middleton, Mcneil & Mills Associates V, LLC
 Middleton, McNeil & Mills Associates VI, LLC
 New Leaf Venture Management II, LLC
 SANDERLING V BETEILIGUNGS GMBH & CO
 SANDERLING V LIMITED PARTNERSHIP
 SANDERLING V VENTURES MANAGEMENT
 SANDERLING VI BETEILIGUNGS GMBH & CO
 SANDERLING VI LIMITED PARTNERSHIP
 SANDERLING VI VENTURES MANAGEMENT
Unavailable10/14Delaware
COHERUS BIOSCIENCES, INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  COHERUS BIOSCIENCES, INC.
 COHERUS BIOSCIENCES, INC
 Impressa Management LLC
Unavailable9/14Delaware
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  SIENTRA, INC.
 ASSOCIATION OF AMERICA
 CLARUS VENTURES I, LLC
 GOLDMAN SACHS PRIVATE EQUITY CONCENTRATED HEALTHCARE OFFSHORE HOLDINGS ADVISORS, INC, ITS GENERAL PARTNERS
 GS PEP 2000 ADVISORS, LLC
 GS PEP 2000 DIRECT INVESTMENT ADVISORS, LLC
 GS PEP 2000 OFFSHORE HOLDINGS ADVISORS, INC
 GS PEP 2002 DIRECT INVESTMENT ADVISORS, LLC
 GS PEP 2002 OFFSHORE HOLDINGS ADVISORS, INC
 GSAM GEN PAR, LLC
 ORBIMED ADVISORS LLC
 ORBIMED CAPITAL GP III LLC
 Sientra, Inc
 TEACHERS INSURANCE
Unavailable9/14California
FOURTH AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  PROTEON THERAPEUTICS INC
 Deer VII & Co Ltd
 Intersouth Associates VI, LLC
 JE Flynn Capital LLC
 MPM Bioventures IV GP LLC
 MPM Bioventures IV LLC
 Pharmstandard International SA
 Prism Venture Partners V, LLC
 Proteon Therapeutics, Inc
 Science Ventures VI (Cayman) Ltd
 Skyline Venture Management IV, LLC
 TVM Life Science Ventures VI GmbH & Co
 Vectis II GP, LLC
Ropes Gray;Bingham McCutchen9/14Massachusetts
KOLLTAN PHARMACEUTICALS, INC. AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  KOLLTAN PHARMACEUTICALS INC
 KOLLTAN PHARMACEUTICALS, INC
Davis Polk;Weil Gotshal9/14New York
INVESTORS' RIGHTS AGREEMENT  NOVATEL WIRELESS INC
 HC2 HOLDINGS 2, INC
 Novatel Wireless, Inc
Unavailable9/14New York
EX-10.1  ENDOSTIM, INC.
Unavailable9/14Delaware
UPLAND SOFTWARE, INC. AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT December 20, 2013  UPLAND SOFTWARE, INC.
 Brian K Beard, Wilson Sonsini Goodrich & Rosati, PC
 Silverback Enterprise Group, Inc
 Upland Software, Inc
Wilson Sonsini9/14Delaware
AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  DERMIRA, INC.
 ATP III GP, Ltd
 Bay City Capital LLC
 Bay City Capital Management V LLC
 Canaan Partners VIII LLC
 Dermira, Inc
 LEERINK HOLDINGS LLC
 LEERINK SWANN CO-INVESTMENT FUND, LLC
 NEA 13 GP, LLC
 NEA Partners 13, Limited Partnership
 NEA VENTURES 2011, LIMITED PARTNERSHIP
 NEW ENTERPRISE ASSOCIATES 13, LIMITED PARTNERSHIP
 Rock Springs GP LLC
 SABBY HEALTHCARE VOLATILITY MASTER FUND, LTD
 Sabby Management, LLC
 Skintelligence, Inc
 Timothy AG
 UCB SA
Fenwick West8/14Delaware
INVESTORS' RIGHTS AGREEMENT  JAGUAR ANIMAL HEALTH, INC.
 Jaguar Animal Health, Inc
 KUNLUN PHARMACEUTICALS LTD
Reed Smith;White Case8/14Delaware
CIVITAS THERAPEUTICS, INC. THIRD AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT TABLE OF CONTENTS  CIVITAS THERAPEUTICS, INC.
 Adage Capital Advisors, LLC
 Adage Capital Partners, GP, LLC
 Alkermes, Inc
 Bay City Capital LLC
 Bay City Capital Management V LLC
 Canaan Partners VIII LLC
 CIVITAS THERAPEUTICS, INC
 Fountain Healthcare Partners Ltd
 Longitude Capital Partners, LLC
 Longitude Venture Partners
 OrbiMed Advisors LLC
 OrbiMed Capital GP V LLC
 Rock Springs GP LLC
 Sofinnova Management VIII, LLC
Greenberg Traurig;O'Melveny Myers;Latham Watkins;Ropes Gray8/14Massachusetts
FIRST AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  DIPLOMAT PHARMACY, INC.
 DIPLOMAT PHARMACY, INC
Unavailable7/14Michigan
FOURTH AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  T2 BIOSYSTEMS, INC.
 Bridge Street Opportunity Advisors, LLC
 CAMROS CAPITAL, LLC
 Flagship Ventures Fund IV General Partner LLC
 Flagship Ventures General Partner LLC
 Flybridge Capital Partners GP I, LLC
 Flybridge Capital Partners GP II, LLC
 HEALTHCARE SYSTEM
 MBD Advisors, LLC
 Physic Ventures Management, LLC
 Polaris Venture Management Co V, LLC
 T2 BIOSYSTEMS, INC
 WS INVESTMENT COMPANY, LLC
Goodwin Procter;McDermott Will;Boies Schiller7/14Massachusetts
YODLEE, INC. NINTH AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  YODLEE INC
 YODLEE, INC
Unavailable6/14New York
AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  LOXO ONCOLOGY, INC.
 Access Industries Management, LLC
 AI LOXO HOLDINGS, LLC
 Aisling Capital Partners III LLC
 LOXO ONCOLOGY, INC
 NEA 14 GP, LTD
 NEA Partners 14, Limited Partnership
 NEA VENTURES 2014, LIMITED PARTNERSHIP
 NEW ENTERPRISE ASSOCIATES 14, LIMITED PARTNERSHIP
 OrbiMed Advisors LLC
 OrbiMed Capital GP V LLC
McDermott Will;Fenwick West6/14New York
AMENDMENT NO. 3 TO SHAREHOLDER RIGHTS AGREEMENT  NEUROMETRIX, INC.
 American Stock Transfer & Trust Company, LLC
 NeuroMetrix, Inc
Unavailable6/14Delaware
TOBIRA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT  TOBIRA THERAPEUTICS, INC.
 Canaan Partners VII LLC
 Domain Associates, LLC
 FHM V, LLC
 Montreux Equity Management IV, LLC
 MONTREUX IV ASSOCIATES, LLC
 One Palmer Square Associates VII, LLC
 Tobira Therapeutics, Inc
Unavailable6/14California
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  INTERSECT ENT, INC.
 CASILLI INVESTMENT PARTNERS
 Cheyenne Partners
 DAG VENTURES GP FUND III, LLC
 DAG Ventures Management III, LLC
 DUANE FAMILY TRUST
 Genesis VC Partners XI, LLC
 HARMONY PARTNERS I, LLC
 Intersect ENT, Inc
 KPCB HOLDING, INC
 LELAND STANFORD JUNIOR UNIVERSITY
 MEDTRONIC, INC
 NVP Associates, LLC
 Osterweis Capital Management
 PINNACLE VENTURES II EQUITY HOLDINGS, LLC
 Pinto TV GP Company, LLC
 Presidio Management Group IX, LLC
 Stanford Management Company
 SVB FINANCIAL GROUP
Unavailable6/14California
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